Modafinil

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Modafinil
Klinicki podaci


Prodajno ime	Modiodal, Provigil, Sparlon
Drugs.com	Monografija
Nacin primene	Oralno
Farmakokineticki podaci
Poluvreme eliminacije	23-215 sati
Izlucivanje	Glavni nacin eliminacije je metabolizam (~90%)

Identifikatori
CAS broj	68693-11-8^Da
ATC kod	N06BA07 (WHO)
PubChem	CID 4236
DrugBank	DB00745^Da
ChemSpider	4088^Da
ChEMBL	CHEMBL1373^Da
Hemijski podaci
Formula	C₁₅H₁₅NO₂S
Molarna masa	273,350
SMILES NC(=O)CS(=O)C(C1=CC=CC=C1)C1=CC=CC=C1
InChI InChI=1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)^Da Key:YFGHCGITMMYXAQ-UHFFFAOYSA-N^Da

Fizicki podaci
Tacka topljenja	164--166 degC (327--331 degF)

Modafinil (Modalert 200)

Modafinil je organsko jedinjenje, koje sadrzi 15 atoma ugljenika i ima molekulsku masu od 273,350 Da.^[1]^[2]^[3]^[4]

Osobine

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Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	1
Broj rotacionih veza	5
Particioni koeficijent^[5] (ALogP)	1,7
Rastvorljivost^[6] (logS, log(mol/L))	-4,3
Polarna povrsina^[7] (PSA, A²)	79,4

Reference

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^ Lindsay SE, Gudelsky GA, Heaton PC. ,,Use of modafinil for the treatment of attention deficit/hyperactivity disorder". Ann Pharmacother. 40 (10): 1829--33. oktobar 2006. PMID 16954326. CS1 odrzhavanje: Format datuma (veza). Epub 2006 Sep 5.
^ Ishizuka T, Sakamoto Y, Sakurai T, Yamatodani A. ,,Modafinil increases histamine release in the anterior hypothalamus of rats". Neurosci Lett. 339 (2): 143--6. mart 2003. PMID 12614915. CS1 odrzhavanje: Format datuma (veza)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). ,,DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs". Nucleic Acids Research. 39 (Database issue): D1035--D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). ,,DrugBank: A knowledgebase for drugs, drug actions and drug targets". Nucleic Acids Research. 36 (Database issue): D901--D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). ,,Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods". The Journal of Physical Chemistry A. 102 (21): 3762--3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). ,,Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices". Journal of Chemical Information and Computer Sciences. 41 (6): 1488--1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). ,,Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties". Journal of Medicinal Chemistry. 43 (20): 3714--3717. PMID 11020286. doi:10.1021/jm000942e.