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Bietaserpine

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Bietaserpine
Names
IUPAC name
Methyl 1-[2-(diethylamino)ethyl]-11,17a-dimethoxy-18b-[(3,4,5-trimethoxybenzoyl)oxy]-3b,20a-yohimban-16b-carboxylate
Systematic IUPAC name
Methyl (1S,2R,3R,4aS,13bR,14aS)-13-[2-(diethylamino)ethyl]-2,11-dimethoxy-3-[(3,4,5-trimethoxybenzoyl)oxy]-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.000.151
UNII
  • InChI=1S/C39H53N3O9/c1-9-40(10-2)15-16-42-29-20-25(45-3)11-12-26(29)27-13-14-41-22-24-19-33(37(49-7)34(39(44)50-8)28(24)21-30(41)35(27)42)51-38(43)23-17-31(46-4)36(48-6)32(18-23)47-5/h11-12,17-18,20,24,28,30,33-34,37H,9-10,13-16,19,21-22H2,1-8H3/t24-,28+,30-,33-,34+,37+/m1/s1 Y
    Key: WFTSRDISOMSAQC-ZNFOTRSXSA-N Y
  • COc1cc(cc(OC)c1OC)C(=O)O[C@@H]4C[C@@H]5CN6CCc3c(n(CCN(CC)CC)c2cc(OC)ccc23)[C@H]6C[C@@H]5[C@H](C(=O)OC)[C@H]4OC
Properties
C39H53N3O9
Molar mass 707.865 g*mol-1
Pharmacology
C02AA07 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 degC [77 degF], 100 kPa).
N verify (what is YN ?)
Chemical compound

Bietaserpine (INN), or 1-[2-(diethylamino)ethyl]reserpine, is a derivative of reserpine used as an antihypertensive agent. Like reserpine, bietaserpine is a VMAT inhibitor.[1]

References

[edit]
  1. ^ Buckingham J et al. (eds.) (1993). Dictionary of Natural Products, vol. 5, p. 4923, Boca Raton: Chapman & Hall/CRC. ISBN 978-0-412-46620-5. Retrieved on June 22, 2009 through Google Book Search.
Sympatholytic (and closely related) antihypertensives (C02)
Sympatholytics
(antagonize a-adrenergic
vasoconstriction)
Central
a2-Adrenergic receptor agonists
Adrenergic release inhibitors
Imidazoline receptor agonists
Ganglion-blocking/nicotinic antagonists
Peripheral
Indirect
Monoamine oxidase inhibitors
VMAT inhibitors
Tyrosine hydroxylase inhibitors
Direct
a1-Adrenergic receptor blockers
Non-selective a-adrenergic receptor blockers
Other antagonists
Serotonin receptor antagonists
Endothelin receptor antagonists (for PHTooltip Pulmonary hypertension)
DATTooltip Dopamine transporter
(DRIsTooltip Dopamine reuptake inhibitors)
NETTooltip Norepinephrine transporter
(NRIsTooltip Norepinephrine reuptake inhibitors)
SERTTooltip Serotonin transporter
(SRIsTooltip Serotonin reuptake inhibitors)
VMATsTooltip Vesicular monoamine transporters
Others


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