Publications85
h-index38
Citations5,709
Highly Influential Citations212
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A sex difference in the human brain and its relation to transsexuality
TLDR
This study is the first to show a female brain structure in genetically male transsexuals and supports the hypothesis that gender identity develops as a result of an interaction between the developing brain and sex hormones. Expand
On the evolution and geometry of the brain in mammals
  • M. Hofman
  • Medicine, Biology
  • Progress in Neurobiology
  • 31 December 1989
At what age is the developing cerebral cortex of the rat comparable to that of the full-term newborn human baby?
TLDR
It is suggested that the 12-13-day-old rat pup fulfills this criterion and should be of use to scientists who use the rat for studying certain processes assumed to occur in the human cerebral cortex around full-term birth. Expand
Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein E-epsilon4/4 genotype.
TLDR
A dramatic decrease in the CSF melatonin levels was found in old control subjects and even more so inAD patients, and whether supplementation of melatonin may indeed improve behavioral disturbances in AD patients should be investigated. Expand
Vasopressin and the Output of the Hypothalamic Biological Clock
TLDR
The remarkable correlation between a diminished presence of vasopressin in the SCN and a deterioration of sleep-wake rhythms during ageing and depression make it likely that, also in humans, the vasopressingin neurones contribute considerably to the rhythmic output of theSCN. Expand
Evolution of the human brain: when bigger is better
  • M. Hofman
  • Medicine, Computer Science
  • Front. Neuroanat.
  • 27 March 2014
TLDR
The object of this review is to present current perspectives on primate brain evolution, especially in humans, and to examine some hypothetical organizing principles that underlie the brain's complex organization. Expand
Living by the clock: The circadian pacemaker in older people
TLDR
The many lines of evidence of age-related decrements in circadian time-keeping and the observed neuronal degeneration of the SCN in senescence strongly suggest that the circadian pacemaker in the human brain becomes progressively disturbed during aging. Expand
Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels
TLDR
It is demonstrated for the first time that CSF melatonin levels were significantly decreased in the aged individuals with early neuropathological changes in the temporal cortex, where the AD process starts, suggesting that the decrease in CSFmelatonin levels may be an early event in the development of AD possibly occurring even before the clinical symptoms. Expand
Energy Metabolism, Brain Size and Longevity in Mammals
  • M. Hofman
  • Medicine, Biology
  • The Quarterly Review of Biology
  • 1 December 1983
TLDR
The maximum potential life span of a mammal was found to be proportional to the product of its degree of encephalization and the reciprocal of its metabolic rate per unit weight. Expand
Size and shape of the cerebral cortex in mammals. I. The cortical surface.
  • M. Hofman
  • Medicine, Biology
  • Brain, behavior and evolution
  • 1985
TLDR
It appears that the use of a single allometric relation in studying the effect of size increase on the geometry of the brain - irrespective of convolutedness or ecological strategy - is unjustified and obscured the differences in the structural organization of mammalian brains. Expand
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